Tuition Singapore H2 H1 Biology Tuition – Cellular Respiration

• Posted on admin
• in Blog
• on December 12, 2015
• No Comments.

Tuition Singapore H2 H1 Biology Tuition – Cellular Respiration

Question

Explain, in detail, how the complete oxidation of one molecule of glucose gives rise to 38 ATP

molecules.

Thinking Process

Ask yourself

• Is this question asking for the description of the whole process of aerobic respiration?
• If not, what are the essential steps you need to distil from aerobic respiration to account for the production of 38 ATP?
• How would you organize your answer?

Answer

Glycolysis

1. Glucose —> glucose-6-phosphate, one ATP expended.
2. Fructose-6-phosphate —> fructose-1,6-bisphosphate, one ATP expended.
3. Two molecules of 1,3-diphosphoglycerate generates four molecules of ATP via substrate level phosphorylation.
4. Net production of two ATP molecules during glycolysis.
5. The oxidation/dehydrogenation of two molecules of glyceraldehyde-3-phosphate by NAD+ to form two molecules of 1,3-diphosphoglycerate generates two NADH.

Link reaction

6. The oxidative decarboxylation of two molecules of pyruvate to form two molecules of acetyl-coA generates two NADH.

Krebs cycle

7. When two molecules of succinyl CoA are converted to two molecules of succinate, two molecules of ATP is produced by substrate-level phosphorylation.
8. The oxidative decarboxylation of two molecules of isocitrate to form two molecules of α-ketoglutarate generates two NADH.
9. The oxidative decarboxylation of two molecules of α-ketoglutarate to form two molecules of succinyl-coA generates two NADH.
10. The oxidation of two molecules of succinate to form two molecules of fumarate generates two FADH2.
11. The oxidation of two molecules of malate to regenerate two molecules of oxaloacetate generates two NADH.

Oxidative phosphorylation

12. Oxidation of one NADH gives 3 ATP
13. Oxidation of one FADH2 gives 2 ATP.
14. 10 NADH + 2 FADH2 + 4 ATP = 38 ATP

Please contact Angie @ 96790470 or Mr Ong @ 98639633 if you need H2?H1 Biology Tuition